Newton works with four fundamental concepts: space, time, matter and force. All four have been swept into limbo by modern physicists. Space and time, for Newton, were solid, independent things. They have been replaced by space-time, which is not substantial but only a system of relations. Matter has had to be replaced by series of events. Force, which was the first of the Newtonian concepts to be abandoned, has been replaced by energy; and energy turns out to be indistinguishable from the pale ghost which is all that remains of matter.
Source: My Philosophical Development, chap. 2,1959
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